Semaglutide mimics a natural hormone in your body, glucagon-like peptide-1 (GLP-1), which plays a major role in your appetite, insulin production, and digestion.
As you eat, your intestines release the GLP-1 hormone to signal to your brain that you’re full and should stop eating. Because semaglutide mimics this function, it essentially “tricks” your body into feeling satisfied with smaller meal portions, helping you maintain a calorie deficit (burning more calories than you consume).
Tirzepatide works similarly, also mimicking the gastric inhibitory polypeptide (GIP) hormone, giving it the ability to further reduce hunger and stabilize blood sugar levels.








